Stavudine

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02952CAS No. ：3056-17-5Purity：98%

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CAS No.	3056-17-5	Cat. No.	BCP02952
Name	Stavudine
Synonyms	Zerit;d4T;
SMILES
Chemical Name
Formula	C10H12N2O4	M. Wt	224.21
Purity	98%	Storage	Store at 4-8°C
Description	Stavudine is a dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. Stavudine is an analog of thymidine. It is phosphorylated by cellular kinases into active triphosphate. Stavudine triphosphate inhibits the HIV reverse transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termination of DNA synthesis by incorporating into it . Mice were treated for 2 weeks with stavudine d4T (500 mg/kg/day), L-carnitine (200 mg/kg/day) or both drugs concomitantly. Body fatness was assessed by dual energy X-ray absorptiometry, and investigations were performed in plasma, liver, muscle and WAT. D4T reduced the gain of body adiposity, WAT leptin, whole body FAO and plasma ketone bodies, and increased liver triglycerides and plasma aminotransferases with mild ultrastructural abnormalities in hepatocytes.