Doxapram

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP04484CAS No. ：309-29-5Purity：98%

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CAS No.	309-29-5	Cat. No.	BCP04484
Name	Doxapram
Synonyms	AHR-619;AHR 619;AHR619;
SMILES
Chemical Name
Formula	C24H30N2O2	M. Wt	378.51
Purity	98%	Storage	Store at 4-8°C
Description	Doxapram is a respiratory stimulant. Doxapram (15-150 microM) also evoked 3H overflow in a concentration dependent manner, and doxapram-evoked release was inhibited by the Ca2+ channel blocker nifedipine (5 microM). Analysis of released tritiated compounds suggested that doxapram preferentially stimulated the release of dopamine. Our results indicate that the mechanism of action of doxapram shares similarities with that of hypoxia in the carotid body. Doxapram (1-100 microM) caused rapid, reversible and dose-dependent inhibitions of K+ currents recorded in type I cells (IC50 approximately 13 microM). doxapram was also seen to directly inhibit Ca(2+)-independent K+ currents. Doxapram was a more potent inhibitor of the Ca(2+)-activated K+ currents recorded under control conditions. Doxapram (10 microM) was without effect on L-type Ca2+ channel currents recorded under conditions where K+ channel activity was minimized and was also without significant effect on K+ currents recorded in the