SKI II
Data Sheet
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| CAS No. | 312636-16-1 | Cat. No. | BCP13169 |
| Name | SKI II | ||
| Synonyms | SKI-II; Sphingosine kinase inhibitor II;SphK-I2; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C15H11ClN2OS | M. Wt | 302.78 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SKI-II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM). nhibits acute myelogenous leukemia cell growth in vitro and in vivo. SKI-II was more efficient than two known SphK1 inhibitors SK1-I and FTY720 in inhibiting AML cells. Meanwhile, it induced dramatic apoptosis in above AML cells, and the cytotoxicity by SKI-II was almost reversed by the general caspase inhibitor z-VAD-fmk. SKI-II treatment inhibited SphK1 activation, and concomitantly increased level of sphingosine-1-phosphate (S1P) precursor ceramide in AML cells. | ||
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