BRD7116
Data Sheet
For research use only. Not for human use.
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| CAS No. | 329059-55-4 | Cat. No. | BCP16037 |
| Name | BRD7116 | ||
| Synonyms | BRD-7116;BRD 7116; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C28H36N2O4S | M. Wt | 496.66 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BRD7116 is a bis-aryl sulfone, shows evidence of stroma-mediated anti-LSCe activity. BRD7116 exhibits an EC50 of 200 nM for LSCe cells in co-culture, whereas it displays limited activity against normal HSPCs and AML cell lines (~50% inhibition at 20 μM). BRD7116 also shows activity against patient-derived, primary human leukemia cells. BRD7116 inhibits LSCs via non-cell-autonomous effects on stromal cells as well as cell-autonomous induction of myeloid differentiation genes in LSCs. | ||
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