AH 6809

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP13216CAS No. ：33458-93-4Purity：98%

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CAS No.	33458-93-4	Cat. No.	BCP13216
Name	AH 6809
Synonyms	AH-6809;AH6809;
SMILES
Chemical Name
Formula	C17H14O5	M. Wt	298.29
Purity	98%	Storage	Store at 4-8°C
Description	AH6809also antagonized the aggregatory effect of U-46619 in whole blood (pA2 = 4.45). However, concentrations of AH6809 up to 300 microM were without effect upon either ADP- or platelet activating factor (Paf)-induced aggregation (pA2 less than 3.5). Preincubation of control cells in 10(-4) M concentrations of AH6809 inhibited PGE2-induced activation of AC by greater than 80% without significant (P greater than .05) inhibition of basal activity by the antagonist. in vivo: Exposure to a selective COX-2 inhibitor (SC58125) or an EP1/EP2 antagonist (AH6809), but not an EP4 antagonist (AH23848B), significantly reduced cell proliferation of esophageal explants in 24 hour-organ culture experiments. Oral administration of the EP1 receptor antagonist, AH6809 (10 mg/kg/day, for 4 days), significantly reduced the systolic blood pressure in db/db, but not in control mice .