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ANX-510 Chemical Structure

ANX-510

Data Sheet For research use only. Not for human use.
Cat. No. :BCP09003CAS No. :3432-99-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 3432-99-3 Cat. No. BCP09003
Name ANX-510
Synonyms ANX-510;ANX 510;ANX510;5,10-methylenetetrahydrofolate;
SMILES
Chemical Name
Formula C20H23N7O6 M. Wt 457.44
Purity 98% Storage Store at 4-8°C
Description ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity.
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