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CP-673451 Chemical Structure

CP-673451

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP04764CAS No. ：343787-29-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 343787-29-1 Cat. No. BCP04764
Name CP-673451
Synonyms CP673451;CP 673451;
SMILES
Chemical Name
Formula C24H27N5O2 M. Wt 417.5
Purity 98% Storage Store at 4-8°C
Description In glioblastoma tumors, CP-673451 (33 mg/kg) provides >50% inhibition of PDGFR-β receptor for 4 hours corresponding to an EC50 of 120 ng/mL in plasma at Cmax. In a sponge angiogenesis model, CP-673451 inhibits 70% of PDGF-BB-stimulated angiogenesis at a dose of 3 mg/kg (q.d. ×5, p.o., corresponding to 5.5 ng/mL at Cmax).[1] CP-673451 decreases cell proliferation rate through mechanisms involving reduced phosphorylation of GSK-3α and GSK-3β. In both RD and RUCH2 cultures, CP-673451 impairs rhabdosphere-forming capacity and cell differentiation, causes increased senescence.
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HPLC H-NMR
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