SNS-032

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01951CAS No. ：345627-80-7Purity：98%

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CAS No.	345627-80-7	Cat. No.	BCP01951
Name	SNS-032
Synonyms	BMS-387032;BMS 387032;BMS387032;SNS032;SNS 032;
SMILES
Chemical Name
Formula	C17H24N4O2S2	M. Wt	380.53
Purity	98%	Storage	Store at 4-8°C
Description	SNS-032 has low sensitivity to CDK1 and CDK4 with IC50 of 480 nM and 925 nM, respectively. SNS-032 effectively kills chronic lymphocytic leukemia cells in vitro regardless of prognostic indicators and treatment history. Compared with flavopiridol and roscovitine, SNS-032 is more potent, both in inhibition of RNA synthesis and at induction of apoptosis. SNS-032 activity is readily reversible; removal of SNS-032 reactivates RNA polymerase II, which led to resynthesis of Mcl-1 and cell survival. SNS-032 inhibits three dimensional capillary network formations of endothelial cells. SNS-032 completely prevents U87MG cell–mediated capillary formation of HUVECs. In addition, SNS-032 significantly prevents the production of VEGF in both cell lines, SNS-032 prevents in vitro angiogenesis, and this action is attributable to blocking of VEGF. Preclinical studies have shown that SNS-032 induces cell cycle arrest and apoptosis across multiple cell lines. SNS-032 blocks the cell cycle via inhibition