SNS-032 tartrate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 345627-92-1 | Cat. No. | BCP06530 |
| Name | SNS-032 tartrate | ||
| Synonyms | SNS 032 tartrate;SNS032 tartrate;BMS387032 tartrate; BMS 387032 tartrate; BMS-387032 tartrate; | ||
| SMILES | CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3.CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3.C(C(C(=O)O)O)(C(=O)O)O | ||
| Chemical Name | |||
| Formula | 2C17H24N4O2S2.C4H6O6 | M. Wt | 911.14 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SNS-032 has low sensitivity to CDK1 and CDK4 with IC50 of 480 nM and 925 nM, respectively. SNS-032 effectively kills chronic lymphocytic leukemia cells in vitro regardless of prognostic indicators and treatment history. Compared with flavopiridol and roscovitine, SNS-032 is more potent, both in inhibition of RNA synthesis and at induction of apoptosis. SNS-032 activity is readily reversible; removal of SNS-032 reactivates RNA polymerase II, which led to resynthesis of Mcl-1 and cell survival.SNS-032 inhibits three dimensional capillary network formations of endothelial cells. SNS-032 completely prevents U87MG cell–mediated capillary formation of HUVECs. In addition, SNS-032 significantly prevents the production of VEGF in both cell lines, SNS-032 prevents in vitro angiogenesis, and this action is attributable to blocking of VEGF. Preclinical studies have shown that SNS-032 induces cell cycle arrest and apoptosis across multiple cell lines. SNS-032 blocks the cell cycle via inhibition o | ||
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