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Maitansine Chemical Structure

Maitansine

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP18204CAS No. ：35846-53-8Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 35846-53-8 Cat. No. BCP18204
Name Maitansine
Synonyms Maytansine;Maytansine;NSC 153858;NSC-153858;NSC153858;
SMILES CC1C2CC(C(C=CC=C(CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)CC(C4(C1O4)C)OC(=O)C(C)N(C)C(=O)C)C)C)OC)(NC(=O)O2)O
Chemical Name
Formula C34H46ClN3O10 M. Wt 692.201
Purity 98% Storage Store at 4-8°C
Description Maytansine, also known as maitansine and NSC153858, is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site. It is a macrolide of the ansamycin type and can be isolated from plants of the genus Maytenus. An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis. Maytansine exhibits cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo.
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