NVP-231

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP15019CAS No. ：362003-83-6Purity：98%

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CAS No.	362003-83-6	Cat. No.	BCP15019
Name	NVP-231
Synonyms	NVP231;NVP 231;
SMILES
Chemical Name
Formula	C25H25N3O2S	M. Wt	431.55
Purity	98%	Storage	Store at 4-8°C
Description	NVP-231 showed an IC50 value of 12 ± 2 nM and 90% inhibition at 100 nM in the radioassay. NVP-231 did not compete with ATP but rather with ceramide, displaying an inhibition constant (Ki) of 7.4 nM. Furthermore, inhibition by NVP-231 was instantaneous and fully reversible, implying that this compound does not covalently modify CerK. At 10 nM, NVP-231 inhibited C1P formation by >50%; at 100 nM, NVP-231 achieved complete inhibition. Thus the potency and efficacy of NVP-231 observed in cell culture are consistent with those found in vitro. It is noteworthy that, NVP-231 did not inhibit GlcCer and SM formation; rather, it increased these metabolites in correlation with compound concentration, demonstrating that NVP-231 does not act as a general inhibitor of ceramide metabolism [1]. The EC(50) of NVP-231 in this assay is in the low nanomolar range, consistent with the IC(50) determined in activity assays in vitro using purified CerK .