NSC177223

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP24669CAS No. ：36707-00-3Purity：98%

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CAS No.	36707-00-3	Cat. No.	BCP24669
Name	NSC177223
Synonyms	NSC-177223;NSC 177223;API1; API-1; API 1;
SMILES
Chemical Name
Formula	C13H15N5O6	M. Wt	337.29
Purity	98%	Storage	Store at 4-8°C
Description	NSC177233 is a potent Akt inhibitor, which induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis . API-1 rapidly and potently reduced the levels of Mcl-1 primarily in API-1-senstive lung cancer cell lines. Ectopic expression of Mcl-1 protected cells from induction of apoptosis by API-1. API-1 treatment decreased the half-life of Mcl-1, whereas inhibition of the proteasome with MG132 rescued Mcl-1 reduction induced by API-1. API-1 decreased Mcl-1 levels accompanied with a rapid increase in Mcl-1 phosphorylation (S159/T163). Moreover, inhibition of GSK3 inhibited Mcl-1 phosphorylation and reduction induced by API-1 and antagonized the effect of API-1 on induction of apoptosis.