BVT 2733
Data Sheet
For research use only. Not for human use.
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| CAS No. | 376640-41-4 | Cat. No. | BCP15782 |
| Name | BVT 2733 | ||
| Synonyms | BVT2733;BVT-2733; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H21ClN4O3S2 | M. Wt | 428.96 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BVT 2733 lowered hepatic PEPCK and glucose-6-phosphatase mRNA, blood glucose and serum insulin concentrations compared with vehicle treated mice. CIA mice were treated with BVT-2733 (100 mg/kg, orally) or vehicle twice daily for 2 weeks. BVT-2733 treatment attenuated the arthritis severity and anti-CII level in CIA mice. BVT-2733 also decreased the levels of serum TNF-α, IL-1β, IL-6 and IL-17. BVT-2733 treatment also significantly reduced synovial inflammation and joint destruction [2]. Mice receiving BVT 2733 treatment exhibited decreased body weight and enhanced glucose tolerance and insulin sensitivity compared to control mice. BVT 2733 also down-regulated the expression of inflammation-related genes including monocyte chemoattractant protein 1 (MCP-1), tumor necrosis factor alpha (TNF-α) and the number of infiltrated macrophages within the adipose tissue in vivo . | ||
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