CC-401

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01960CAS No. ：395104-30-0Purity：98%

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CAS No.	395104-30-0	Cat. No.	BCP01960
Name	CC-401
Synonyms	CC 401;CC401;CAS:862832-38-0;
SMILES
Chemical Name
Formula	C22H24N6O	M. Wt	388.47
Purity	98%	Storage	Store at 4-8°C
Description	In vitro: JNK inhibition decreased cytochrome c release, caspase 3 activation (P<0.05), and lipid peroxidation (P<0.05). JNK inhibition also transiently blocked phosphorylation of c-Jun at 60 minutes after reperfusion (P<0.05) without affecting other MAPK signaling, including p-38 and Erk activation. in vivo: In acute disease, CC-401 blocked JNK signaling and reduced proteinuria in the first 24 h. The transient neutrophil influx seen at 3 h of disease was not affected, however. Continued CC-401 treatment suppressed glomerular and tubulointerstitial damage usually seen at 14 days. Administration of CC-401 to rats prior to bilateral renal I/R prevented acute renal failure and largely prevented tubular damage, leucocyte infiltration and upregulation of pro-inflammatory molecules. However, delaying CC-401 treatment until 1 h after reperfusion (after the peak of JNK activation) had no protective effect .