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Firategrast Chemical Structure

Firategrast

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP18576CAS No. ：402567-16-2Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 402567-16-2 Cat. No. BCP18576
Name Firategrast
Synonyms SB-683699; SB 683699; SB683699; T-0047; T 0047; T0047;
SMILES O=C(O)[C@@H](NC(C1=C(F)C=CC=C1F)=O)CC2=CC=C(C3=C(OC)C=C(COCC)C=C3OC)C=C2
Chemical Name
Formula C27H27F2NO6 M. Wt 499.5
Purity 98% Storage Store at 4-8°C
Description Firategrast, also known as SB-683699 or T-0047, is an orally bioavailable alpha4 beta1/alpha4 beta7 integrin antagonist designed to reduce trafficking of lymphocytes into the central nervous system (CNS). This could decrease multiple sclerosis (MS) activity, but may compromise CNS immune surveillance. The integrins are a sort of transmembrane receptors that modulate the signal transduction from ECM to the cell. They are associated with a lot of diseases such as cancer, inflammation and thrombotic diseases.
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