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Salubrinal Chemical Structure

Salubrinal

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP06507CAS No. ：405060-95-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 405060-95-9 Cat. No. BCP06507
Name Salubrinal
Synonyms SAL;
SMILES
Chemical Name
Formula C21H17Cl3N4OS M. Wt 479.81
Purity 98% Storage Store at 4-8°C
Description Salubrinal suppressed CdCl2-induced cellular damage and cell death. The resulting maintenance of protein phosphorylation results in enhanced protection from the adverse effects of initiators of the unfolded protein response. Salubrinal can also interact with the anti-apoptotic protein Bcl-2, inhibiting binding of the non-peptidic antagonist HA14-1 and of a porphycene that can catalyze Bcl-2 photodamage. As a result, salubrinal offers protection from the apoptotic and autophagic effects that can result from loss of Bcl-2 function. Treatment with salubrinal reduced the number of TUNEL-positive cells and the cleavages of caspase-3 and poly(ADP-ribose) polymerase, but not the cleavage of light chain 3B, indicating protection from CdCl2-induced apoptosis but not autophagy.
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LCMS H-NMR
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