Bruceantin
Data Sheet
For research use only. Not for human use.
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| CAS No. | 41451-75-6 | Cat. No. | BCP10096 |
| Name | Bruceantin | ||
| Synonyms | (-)-Bruceantin;NCI165563;NSC165563;NSC-165563; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C28H36O11 | M. Wt | 548.58 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Cell differentiation was induced and c-MYC was down-regulated, suggesting a mechanistic correlation between c-MYC down-regulation and induction of cell differentiation or cell death. Treatment of HL-60 and RPMI 8226 cell lines induced apoptosis, and this involved the caspase and mitochondrial pathways. Moreover, an in vivo study using RPMI 8226 human-SCID xenografts demonstrated that bruceantin induced regression in early as well as advanced tumors, and these significant antitumor responses were facilitated in the absence of overt toxicity. | ||
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