Lenvatinib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01799CAS No. ：417716-92-8Purity：98%

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CAS No.	417716-92-8	Cat. No.	BCP01799
Name	Lenvatinib
Synonyms	E7080;Vargatef;E-7080;E 7080;
SMILES
Chemical Name
Formula	C21H19ClN4O4	M. Wt	426.85
Purity	98%	Storage	Store at 4-8°C
Description	E7080, as a potent inhibitor of in vitro angiogenesis, shows a significantly inhibitory effect on VEGF/KDR and SCF/Kit signaling. According to the in vitro receptor tyrosine and serine/threonine kinase assays, E7080 inhibits Flt-1, KDR, Flt-4 with IC50 of 22, 4.0 and 5.2 nM, respectively. In addition to these kinases, E7080 also inhibits FGFR1 and PDGFR tyrosine kinases with IC50 value of 46, 51 and 100 nM for FGFR1, PDGFRα and PDGFRβ, respectively. E7080 potently inhibits phosphorylation of VEGFR2 (IC50, 0.83 nM) and VEGFR3 (IC50, 0.36 nM) in HUVECs which is stimulated by VEGF and VEGF-C, respectively. A recent study shows that E7080 treatment (both at 1 μM and 10 μM) results in a significant inhibition of cell migration and invasion by inhibiting FGFR and PDGFR signaling.