C188-9
Data Sheet
For research use only. Not for human use.
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| CAS No. | 432001-19-9 | Cat. No. | BCP28881 |
| Name | C188-9 | ||
| Synonyms | STAT3 inhibitor TTI-101;TTI101;TTI-101;C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C27H21NO5S | M. Wt | 471.114 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | C188-9 is a STAT3 inhibitor. HDM-induced airway inflammation, remodeling, and Th2/Th17-type cell accumulation involve STAT3 activation that can be prevented by C188-9 treatment. STAT3 inhibition with C188-9 resulted in attenuated skin fibrosis, myofibroblast accumulation, pro-fibrotic gene expression and collagen deposition in both mouse models of skin fibrosis. C188-9 decreased in vitro dermal fibroblast production of fibrotic genes induced by IL-6 trans-signalling and TGF-β. Finally, TGF-β induced phosphotyrosylation of STAT3 in a SMAD3-dependent manner. | ||
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