Lasmiditan succinate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 439239-92-6 | Cat. No. | BCP17272 |
| Name | Lasmiditan succinate | ||
| Synonyms | COL-144; COL144; COL 144; LY573144; LY-573144; LY 573144; | ||
| SMILES | CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=C(C=C(C=C3F)F)F.CN1CCC(CC1)C(=O)C2=NC(=CC=C2)NC(=O)C3=C(C=C(C=C3F)F)F.C(CC(=O)O)C(=O)O | ||
| Chemical Name | |||
| Formula | C42H42F6N6O8 | M. Wt | 872.82 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Lasmiditan succinate is a novel and selective 5-HT(1F) receptor agonist with Ki of 2.1 nM versus Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively. For the understanding of migraine pathophysiology, it is very important to note that a selective 5-HT(1F) receptor agonist like lasmiditan is effective in the acute treatment of migraine. Thus, migraine can be treated with a drug that has no vasoconstrictor ability. While lasmiditan most likely is effective in the treatment of migraine attacks it had, unfortunately, a high incidence of CNS related AEs in the oral RCT. If confirmed in larger studies in phase III, this might adversely limit the use of this highly specific non-vascular acute treatment of migraine. Larger studies including the parameters of patients' preferences are necessary to accurately position this new treatment principle in relation to the triptans. | ||
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