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GW 627368X Chemical Structure

GW 627368X

Data Sheet For research use only. Not for human use.
Cat. No. :BCP15277CAS No. :439288-66-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 439288-66-1 Cat. No. BCP15277
Name GW 627368X
Synonyms GW 627368X; GW-627368X; GW627368; GW 627368; GW-627368;
SMILES O=C(NS(=O)(C1=CC=CC=C1)=O)CC2=CC=C(N(CC3=C4C(OCC)=C(C=CC=C5)C5=C3OCC)C4=O)C=C2
Chemical Name
Formula C30H28N2O6S M. Wt 544.62
Purity 98% Storage Store at 4-8°C
Description GW627368X is a novel, potent and selective competitive antagonist of prostanoid EP4 receptors with additional human TP receptor affinity. Oral administration of GW627368X showed significant tumor regression characterized by tumor reduction and induction of apoptosis. Reduction in prostaglandin E2 synthesis also led to reduced level of VEGF in plasma. GW627368X will be a valuable tool to explore the role of the prostanoid EP4 receptor in many physiological and pathological settings.
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