JNJ7706621

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01836CAS No. ：443797-96-4Purity：98%

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CAS No.	443797-96-4	Cat. No.	BCP01836
Name	JNJ7706621
Synonyms	JNJ-7706621;JNJ 7706621;
SMILES
Chemical Name
Formula	C15H12F2N6O3S	M. Wt	394.36
Purity	98%	Storage	Store at 4-8°C
Description	JNJ-7706621 also shows some inhibition to VEGF-R2, FGF-R2, and GSK3β, with IC50 of 154-254 nM. JNJ-7706621 shows inhibitory effect on a panel of human cancer cell types, including HeLa, HCT-116, SK-OV-3, PC3, DU145, A375, MDA-MB-231, MES-SA, and MES-SA/Dx5, with IC50 of 112-514 nM, independent of p53, retinoblastoma, or P-glycoprotein status. JNJ-7706621 is several-fold less potent at inhibiting growth of normal cell types, including MRC-5, HASMC, HUVEC, and HMVEC, with IC50 of 3.67-5.42 μM. In HeLa or U937 cells, JNJ-7706621 (0.5-3 μM) delays exit from G1, arrests cells in G2-M, induces endoreduplication, activates apoptosis, and reduces colony formation. In a HeLa cell line, incremental treatment with increasing concentrations of JNJ-7706621 leads to a 16-fold resistance, which may be mediated by ABCG2.