NS1643

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP15446CAS No. ：448895-37-2Purity：98%

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CAS No.	448895-37-2	Cat. No.	BCP15446
Name	NS1643
Synonyms	NS-1643;NS 1643;
SMILES
Chemical Name
Formula	C15H10F6N2O3	M. Wt	380.24
Purity	98%	Storage	Store at 4-8°C
Description	NS1643 enhanced the magnitude of wild-type hERG current in a concentration- and voltage-dependent manner with an EC(50) of 10.4 microM at -10 mV. The fully activated current-voltage relationship revealed that the drug increased outward but not inward currents, consistent with altered inactivation gating. NS1643 shifted the voltage dependence of inactivation by +21 mV at 10 microM and +35 mV at 30 microM, but it did not alter the voltage dependence of activation of hERG channels. In Xenopus laevis oocytes, NS1643 increased both steady-state and tail current at all voltages tested. The EC(50) value for HERG channel activation was 10.5 microM. NS1643 also activates the ERG2 channel; however, the molecular mechanism of the activation differs between the ERG1 and ERG2 channels. For ERG2, NS1643 causes a left-ward shift of the activation curve, a faster time-constant of activation and a slower time-constant of inactivation as well as an increased relative importance for the fast component of