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Motesanib Chemical Structure

Motesanib

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01982CAS No. ：453562-69-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 453562-69-1 Cat. No. BCP01982
Name Motesanib
Synonyms AMG706; AMG 706;AMG-706;
SMILES
Chemical Name
Formula C22H23N5O M. Wt 373.46
Purity 98% Storage Store at 4-8°C
Description Motesanib Diphosphate has broad activity against the human VEGFR family, and displays >1000 selectivity against EGFR, Src, and p38 kinase. Motesanib Diphosphate significantly inhibits VEGF-induced cellular proliferation of HUVECs with an IC50 of 10 nM, while displaying little effect at bFGF-induced proliferation with an IC50 of >3,000 nM. Motesanib Diphosphate also potently inhibits PDGF-induced proliferation and SCF-induced c-kit phosphorylation with IC50 of 207 nM and 37 nM, respectively, but not effective against the EGF-induced EGFR phosphorylation and cell viability of A431 cells.Althouth displaying little antiproliferative activity on cell growth of HUVECs alone, Motesanib Diphosphate treatment significantly sensitizes the cells to fractionated radiation
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