SW033291
Data Sheet
For research use only. Not for human use.
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| CAS No. | 459147-39-8 | Cat. No. | BCP15631 |
| Name | SW033291 | ||
| Synonyms | SW-033291;SW 033291; | ||
| SMILES | NC1=C(S(CCCC)=O)SC2=NC(C3=CC=CS3)=CC(C4=CC=CC=C4)=C21 | ||
| Chemical Name | |||
| Formula | C21H20N2OS3 | M. Wt | 412.59 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SW033291 is a potent and selective 15-hydroxyprostaglandin dehydrogenase (15-PGDH) enzyme inhibitor. 15-PGDH is a prostaglandin-degrading enzyme, potentiates tissue regeneration in multiple organs in mice. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. SW033291 also promotes tissue regeneration in mouse models of colon and liver injury. Tissues from 15-PGDH knockout mice demonstrate similar increased regenerative capacity. Thus, 15-PGDH inhibition may be a valuable therapeutic strategy for tissue regeneration in diverse clinical contexts. | ||
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