Selexipag New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP09146CAS No. ：475086-01-2Purity：98%

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CAS No.	475086-01-2	Cat. No.	BCP09146
Name	Selexipag
Synonyms	NS-304; NS304; NS 304; ACT-293987; ACT293987; ACT 293987;
SMILES
Chemical Name
Formula	C26H32N4O4S	M. Wt	496.62
Purity	98%	Storage	Store at 4-8°C
Description	NS-304 is an orally available and potent agonist for the PGI(2) receptor (IP receptor). The inhibition constant (K(i)) of MRE-269 for the human IP receptor was 20 nM; in contrast, the K(i) values for other prostanoid receptors were >2.6 microM. MRE-269 was therefore a highly selective agonist for the IP receptor. The plasma concentrations of MRE-269 remained near peak levels for more than 8 h after oral administration of NS-304 to rats and dogs, and NS-304 increased femoral skin blood flow in rats in a long-lasting manner without affecting the hemodynamics. These findings indicate that NS-304 acts as a long-acting IP receptor agonist in vivo. The continuous vasodilation evoked by NS-304 was not attenuated by repeated treatment, indicating that NS-304 is unlikely to cause severe desensitization of the IP receptor in rats.