(+)-Bicuculline
Data Sheet
For research use only. Not for human use.
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| CAS No. | 485-49-4 | Cat. No. | BCP04180 |
| Name | (+)-Bicuculline | ||
| Synonyms | |||
| SMILES | |||
| Chemical Name | |||
| Formula | C20H17NO6 | M. Wt | 367.35 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | (+)-Bicuculline (1-100μM) dose-dependently inhibits the Cl- conductance generated by 40 μM GABA. (+)-Bicuculline also inhibits the agonist action of GABA at 40 μM at α1β2γ2L receptors. (+)-Bicuculline at 1 and 3 μM increases GABA EC50 values 1.6 times (41.0-67.0 μM) and 3.6 times (36.1-129.0 μM), respectively. Atα1β2γ2L GABAA receptors, (+)-bicuculline displays the general property of the competitive antagonist, producing a parallel shift of GABA concentration-effect curves and having no effect on the maximal response of GABA. In addition to being a potent GABAA receptor antagonist, (+)-bicuculine also blocks Ca2+-activated potassium channels. | ||
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