Thalidomide New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 50-35-1 | Cat. No. | BCP19772 |
| Name | Thalidomide | ||
| Synonyms | Thalomid; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C13H10N2O4 | M. Wt | 258.23 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF-alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In addition, thalidomide inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), thereby inhibiting angiogenesis. | ||
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