PNU120596

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02434CAS No. ：501925-31-1Purity：98%

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CAS No.	501925-31-1	Cat. No.	BCP02434
Name	PNU120596
Synonyms	PNU 120596;PNU-120596;
SMILES
Chemical Name
Formula	C13H14ClN3O4	M. Wt	311.72
Purity	98%	Storage	Store at 4-8°C
Description	PNU-120596 increases agonist (Ach)-evoked calcium flux mediated by an engineered variant of the human α7 nAChR. PNU-120596 increases agonists (choline and ACh)-evoked currents mediated by wild-type receptors and also demonstrates a pronounced prolongation of the evoked response in the continued presence of agonist in Xenopus oocytes. PNU-120596 increases the channel mean open time ofα7 nAChRs but has no effect on ion selectivity and relatively little, if any, effect on unitary conductance. When applied to acute hippocampal slices, PNU-120596 increases the frequency of ACh-evoked GABAergic postsynaptic currents measured in pyramidal neurons; this effect is suppressed by TTX, suggesting that PNU-120596 modulates the function of α7 nAChRs located on the somatodendritic membrane of hippocampal interneurons. Besides the positive modulation to α7 nAChR, PNU-120596 induces a profound retardation of the kinetics of desensitization, raising the potential of Ca2+-induced toxicity through excessi