SB705498
Data Sheet
For research use only. Not for human use.
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| CAS No. | 501951-42-4 | Cat. No. | BCP22698 |
| Name | SB705498 | ||
| Synonyms | SB-705498;SB 705498; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H16BrF3N4O | M. Wt | 429.23 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SB-705498 is an orally bioavailable, competitive antagonist of the capsaicin-mediated activation of TRPV1 receptors (pKis = 7.6, 7.5, and 7.3 for human, rat, and guinea pig, respectively). SB-705498 inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor. SB-705498 was shown to be a potent competitive antagonist of the capsaicin-mediated activation of the human TRPV1 receptor (pK(i) = 7.6) with activity at rat (pK(i) = 7.5) and guinea pig (pK(i) = 7.3) orthologs. | ||
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