Apixaban New
Data Sheet
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| CAS No. | 503612-47-3 | Cat. No. | BCP02451 |
| Name | Apixaban | ||
| Synonyms | BMS56224701; BMS 56224701; BMS-56224701; BMS562247-01;BMS 562247-01;BMS-562247-01; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C25H25N5O4 | M. Wt | 459.5 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Apixaban exhibits a high degree of potency, selectivity, and efficacy on Factor Xa with Ki of 0.08 nM and 0.17 nM for Human Factor Xa and Rabbit Factor Xa, respectively.In vitro, Apixaban prolongs the clotting times of normal human plasma with the concentrations (EC2x) of 3.6 μM, 0.37 μM, 7.4 μM, and 0.4 μM, which are required respectively to double the prothrombin time (PT), modified prothrombin time (mPT), activated partial thromboplastin time (APTT) and HepTest. Besides, Apixaban shows the highest potency in human and rabbit plasma, but less potency in rat and dog plasma in both the PT and APTT assays. | ||
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