TPCA-1 New
Data Sheet
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| CAS No. | 507475-17-4 | Cat. No. | BCP05956 |
| Name | TPCA-1 | ||
| Synonyms | TPCA1;TPCA 1; | ||
| SMILES | O=C(C1=C(NC(N)=O)SC(C2=CC=C(F)C=C2)=C1)N | ||
| Chemical Name | |||
| Formula | C12H10FN3O2S | M. Wt | 279.29 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TPCA-1 is a potent IKK-2 inhibitor. TPCA-1 is also an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation in vivo. It selectively repressed proliferation of NSCLC cells with constitutive STAT3 activation. TPCA-1 as a direct dual inhibitor for both IKKs and STAT3, whereas treatment targeting EGFR only could not sufficiently repress NF-κB and STAT3 pathways for lung cancers harboring mutant EGFR. Therefore, synergistic treatment of TPCA-1 with TKIs has potential to be a more effective strategy for cancers. | ||
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