Mizoribine

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02879CAS No. ：50924-49-7Purity：98%

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CAS No.	50924-49-7	Cat. No.	BCP02879
Name	Mizoribine
Synonyms	HE-69;HE 69;HE69;NSC-289637;NSC289637;NSC 289637;Bredinin;
SMILES
Chemical Name
Formula	C9H13N3O6	M. Wt	259.22
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: Unlike azathioprine, Mizoribine is not taken up by nucleic acids in the cell. Instead, after phosphorylation MZR-5 -monophosphate inhibits GMP synthesis by the antagonistic blocking of IMPDH (Ki = 10(-8)M) and GMP- synthetase (Ki =10(-5) M) . Pretreatment of cells with MZR partially, but significantly, attenuates the expression of monocyte chemoattractant protein (MCP)-1 mRNA and protein, whereas the poly IC-induced expressions for the other functional molecules, such as CCL5, fractalkine and IL-8 were not influenced by MZR treatment . in vivo:MZR 150 mg was administered once a day. After 6 months, the remission rate was 72.7% (2 subjects achieved complete remission, and 9 partial remission). After 3 and 6 months, significant reductions (p < 0.01) were obtained in 24-h proteinuria (g/day) .