Diosgenin
Data Sheet
For research use only. Not for human use.
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| CAS No. | 512-04-9 | Cat. No. | BCP06706 |
| Name | Diosgenin | ||
| Synonyms | |||
| SMILES | |||
| Chemical Name | |||
| Formula | C27H42O3 | M. Wt | 414.62 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Diosgenin is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam, such as the Kokoro. The sugar-free (aglycone), diosgenin is used for the commercial synthesis of cortisone, pregnenolone, progesterone, and other steroid products. Diosgenin also causes an inhibition of the growth of fibroblast-like synoviocytes from human rheumatoid arthritis, with apoptosis induction associated with cyclooxygenase-2 (COX-2) up-regulation. Celecoxib, a selective COX-2 inhibitor, provoked a large decrease in diosgenin-induced apoptosis even in the presence of exogenous prostaglandin E2, whereas interleukin-1β, a COX-2 inducer, strongly increased diosgenin-induced apoptosis of these synoviocytes. | ||
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