Matrine

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP08193CAS No. ：519-02-8Purity：98%

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CAS No.	519-02-8	Cat. No.	BCP08193
Name	Matrine
Synonyms	Sophocarpidine;Matridin-15-one;Vegard;α-Matrine;
SMILES
Chemical Name
Formula	C15H24N2O	M. Wt	248.37
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: MTT assay showed that the matrine was able to inhibit gastric cancer cell line MNK45 in a dose-dependent manner. The concentration required for 50% inhibition (IC50) was found to be 540 μg/ml. This anti-tumor function was achieved through modulation of the NF-κB, XIAP, CIAP, and p-ERK proteins expression in cell line MNK45. Matrine induces apoptosis of human NSCLC cells with anti-apoptotic factors inhibited and dependent on caspase activity. In addition, we found that matrine increases the phosphorylation of p38 but not its total protein, and inhibition of the p38 pathway with SB202190 partially prevents matrine-induced apoptosis. Furthermore, matrine generates reactive oxygen species (ROS) in a dose- and time-dependent manner, which is reversed by pretreatment with N-acetyl-L-cysteine (NAC). in vivo: Oral administration of matrine (200, 100 and 50 mg/kg) significantly attenuated isoproterenol-induced cardiac necrosis and left ventricular dysfunction [3]. high dose of matrine