Thio-TEPA
Data Sheet
For research use only. Not for human use.
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| CAS No. | 52-24-4 | Cat. No. | BCP04110 |
| Name | Thio-TEPA | ||
| Synonyms | Triethylenethiophosphoramide;AI3 24916; AI324916; AI3-24916; NSC-6396; NSC 6396; NSC6396; | ||
| SMILES | S=P(N1CC1)(N2CC2)N3CC3 | ||
| Chemical Name | |||
| Formula | C6H12N3PS | M. Wt | 189.22 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Thio-TEPA is a polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth. | ||
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