Deguelin

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01906CAS No. ：522-17-8Purity：98%

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CAS No.	522-17-8	Cat. No.	BCP01906
Name	Deguelin
Synonyms	(-)-Deguelin;(-)-cis-Deguelin;
SMILES
Chemical Name
Formula	C23H22O6	M. Wt	394.42
Purity	98%	Storage	Store at 4-8°C
Description	Deguelin in a dose and time dependent manner inhibited the growth of MDA-MB-231, MDA-MB-468, BT-549 and BT-20 cells. Deguelin administration causes a significant HNSCC cell death. Deguelin induces both cell apoptosis and autophagy by modulating multiple signaling pathways in cultured HNSCC cells. Deguelin inhibits Akt signaling, and down-regulates survivin and cyclin-dependent kinase 4 (Cdk4) expressions, by disrupting their association with heat shock protein-90 (Hsp-90). Deguelin induces ceramide production through de novo synthase pathway to promote HNSCC cell death. Importantly, increased ceramide level activates AMP-activated protein kinase (AMPK), which then directly phosphorylates Ulk1 and eventually leads to cell autophagy. Deguelin inhibited the proliferation of MPC-11 cells in a concentration- and time-dependent manner and caused the apoptotic death of MPC-11 cells. Following exposure to deguelin, the phosphorylation of Akt was decreased. The inhibition of cell growth may be