9-Hydroxyellipticine Hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 52238-35-4 | Cat. No. | BCP11301 |
| Name | 9-Hydroxyellipticine Hydrochloride | ||
| Synonyms | Ellipticine Analog;9-hydroxyellipticine hydrochloride; Hydroxyellipticine; 9-Hydroxyellipticin; NSC 210717; IGIG 929; IGIG929; IGIG-929; LS133324; LS-133324; LS 133324; | ||
| SMILES | CC1=C2C(=C(C3=C1C=CN=C3)C)C4=C(N2)C=CC(=C4)O.Cl | ||
| Chemical Name | |||
| Formula | C17H15ClN2O | M. Wt | 298.77 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | 9-hydroxyellipticine, also known as IGIG 929 and LS133324, is a potent cytotoxic and antitumor agent. Structurally, 9-hydroxyellipticine is a 9-hydroxy derivative of ellipticine. The hydroxy group in 9-hydroxyellipticines increases the apparent affinity for DNA, stabilisation of toposiomerase II-DNA cleavable complex, oxidation to reactive quinone-imine intermediates, phosphorylation of p53 suppressor proteins and cytotoxicity relative to the parent ellipticines. | ||
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