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CAS No. | 524-12-9 | Cat. No. | BCP19859 |
Name | Wedelolactone | ||
Synonyms | |||
SMILES | |||
Chemical Name | |||
Formula | C16H10O7 | M. Wt | 314.25 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Wedelolactone is a potent Î2-arrestin-biased G protein-coupled receptor-35 (GPR35) agonist, GPR35 has been shown to be a target of the asthma drugs cromolyn disodium and nedocromil sodium. Wedelolactone has anti-inflammatory, growth inhibitory, anti-cancer, anti-fibrotic, and pro-apoptotic effects. Wedelolactone stimulates ER genomic and non-genomic signalling pathways; it can significantly inhibit the activation of LX-2 cells, the underlying mechanisms of which included inducing Bcl-2 family involved apoptosis, up-regulating phosphorylated status of ERK and JNK expressions, and inhibiting NF-κB mediated activity. |
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