T-5224
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CAS No. | 530141-72-1 | Cat. No. | BCP14701 |
Name | T-5224 | ||
Synonyms | T 5224;T5224; | ||
SMILES | OC1=NOC2=CC(COC3=C(CCC(O)=O)C=C(C(C4=C(O)C=C(OC5CCCC5)C=C4)=O)C=C3)=CC=C21 | ||
Chemical Name | |||
Formula | C29H27NO8 | M. Wt | 517.53 |
Purity | 98% | Storage | Store at 4-8°C |
Description | T-5224 is a selective inhibitor of c-Fos/activator protein-1. T-5224 ameliorates liver injury and improves survival through decreasing production of proinflammatory cytokines and chemokines in endotoxemic mice. T-5224 has been investigated in phase II human clinical trials. T-5224 may be a promising new treatment for septic kidney injury. Activator protein 1 (AP-1) is a pivotal transcription factor that regulates a wide range of cellular processes including proliferation, apoptosis, differentiation, survival, cell migration, and transformation. |
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