Mefloquine New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP09262CAS No. ：53230-10-7Purity：98%

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CAS No.	53230-10-7	Cat. No.	BCP09262
Name	Mefloquine
Synonyms	Lariam; Ro 215998; Ro-215998; Ro215998; WR 142490; WR-142490; WR142490;
SMILES	C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O
Chemical Name
Formula	C17H16F6N2O	M. Wt	378.32
Purity	98%	Storage	Store at 4-8°C
Description	Mefloquine is a quinolinemethanol derivative with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the exact mechanism remains to be elucidated, mefloquine, a weak base, preferentially accumulates in lysosomes and disrupts lysosomal function and integrity, thereby leading to host cell death. Similar to chloroquine, the chemosensitizing and radiosensitizing activities of this agent may be related to its inhibition of autophagocytosis, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species (ROS) related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Compared to chloroquine, mefloquine has better blood-brain-barrier (BBB) penetration.