Isoniazid

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP13791CAS No. ：54-85-3Purity：98%

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CAS No.	54-85-3	Cat. No.	BCP13791
Name	Isoniazid
Synonyms	INH;Isonicotinic acid hydrazide; Isonicotinic hydrazide;Tubizid;Laniazid;Nydrazid;Isonicotinylhydrazine;
SMILES
Chemical Name
Formula	C6H7N3O	M. Wt	137.14
Purity	98%	Storage	Store at 4-8°C
Description	Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824. Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing.