PNRI-299

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP16043CAS No. ：550368-41-7Purity：98%

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CAS No.	550368-41-7	Cat. No.	BCP16043
Name	PNRI-299
Synonyms	PNRI299;PNRI 299;
SMILES
Chemical Name
Formula	C21H15N5O4	M. Wt	401.37
Purity	98%	Storage	Store at 4-8°C
Description	PNRI-299 specifically reacts with Ref-1, inhibits AP-1 transcription, and overexpression of the molecular target. Ref-1 attenuates PNRI-299 inhibition of AP-1 transcription. PNRI-299 interacts with the redox nucleophile Cys-65, to aid in the interpretation of structure activity relationships (SARs). in vivo: Treatment with PNRI-299 significantly decreased the influx of eosinophils, monocytes, and macrophages (no significant reduction of lymphocytes was observed) into the lung interstitium and bronchoalveolar lavage fluid, and airway mucus and edema observed in OVA-treated mice.PNRI-299 reduces the pathophysiological responses seen in this murine model of allergic asthma. PNRI-299 had no effects on the inflammatory changes or lethality induced by I/R injury.