A-674563
Data Sheet
For research use only. Not for human use.
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| CAS No. | 552325-73-2 | Cat. No. | BCP02557 |
| Related Products | A674563HCl（A674563 HCl） | ||
| Name | A-674563 | ||
| Synonyms | A 674563;A674563; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H22N4O | M. Wt | 358.44 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | A-674563 is achieved from A-443654 by replacing the indole with a phenyl moiety and getting oral activity. A-674563 slows proliferation of tumor cells with EC50 of 0.4 μM. [1] A-674563 does not inhibit Akt phosphorylation per se, but blocks the phosphorylation of Akt downstream targets in a dose-dependent manner. A-674563 induced Akt blockade results in decreased STS cell downstream target phosphorylation and tumor cell growth inhibiton. A-674563 induces G2 cell cycle arrest and apoptosis in STS cells. | ||
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