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Laropiprant Chemical Structure

Laropiprant

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP02136CAS No. ：571170-77-9Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 571170-77-9 Cat. No. BCP02136
Name Laropiprant
Synonyms Cardaptive;MK 0524;MK-0524;MK0524;
SMILES
Chemical Name
Formula C21H19ClFNO4S M. Wt 435.9
Purity 98% Storage Store at 4-8°C
Description Laropiprant(Cardaptive; MK 0524) inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC50 values of 0.09 and 4.0 nM, respectively. In a sheep model of allergic rhinitis, 0.1 mg/kg MK 0524 completely blocked PGD2-induced nasal congestion. At a dose of 4 mg/kg, MK 0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a murine model of flushing, an undesirable side-effect of niacin treatment for dyslipidemia.
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