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Clozapine Chemical Structure

Clozapine

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP25196CAS No. ：5786-21-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 5786-21-0 Cat. No. BCP25196
Name Clozapine
Synonyms HF 1854;HF-1854;HF1854;
SMILES
Chemical Name
Formula C18H19ClN4 M. Wt 326.82
Purity 98% Storage Store at 4-8°C
Description Clozapine is an antipsychotic used to treat schizophrenia. Clozapine is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for M1 receptor.Clozapine is an atypical antipsychotic drug because it binds to serotonin as well as dopamine receptors. Clozapine is a partial agonist at the 5-HT1A subunit of the serotonin receptor, putatively improving depression, anxiety, and the negative cognitive symptoms associated with schizophrenia. A direct interaction of clozapine with the GABAB receptor has also been shown. GABAB receptor-deficient mice exhibit increased extracellular dopamine levels and altered locomotor behaviour equivalent to that in schizophrenia animal models.
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