Miltefosine

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP04506CAS No. ：58066-85-6Purity：98%

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CAS No.	58066-85-6	Cat. No.	BCP04506
Name	Miltefosine
Synonyms	Miltefosin;
SMILES
Chemical Name
Formula	C21H46NO4P	M. Wt	407.57
Purity	98%	Storage	Store at 4-8°C
Description	Miltefosine is an alkylphosphocholine drug with demonstrated activity against various parasite species and cancer cells as well as some pathogenic bacteria and fungi. Miltefosine inhibits PKC from NIH3T3 cells in cell-free extracts with a IC50 of about 7 μM.Miltefosine targets HIV infected macrophages, which play a role in vivo as long-lived HIV-1 reservoirs. Miltefosine acts by inhibiting the PI3K/Akt pathway, thus removing the infected macrophages from circulation, without affecting healthy cells.Miltefosine inhibits the PI3K/Akt survival pathway in carcinoma cell lines.Miltefosine causes skeletal muscle insulin resistance in vitro by interfering with the insulinsignalling pathway and inhibiting insulin-stimulated glucose uptake. Miltefosine inhibits insulin-stimulated Akt phosphorylation in a dose-dependent manner with 75% inhibition at 40 μM and 98% inhibition at 60 μM.