BMS-265246

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02546CAS No. ：582315-72-8Purity：98%

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CAS No.	582315-72-8	Cat. No.	BCP02546
Name	BMS-265246
Synonyms	BMS265246;BMS 265246;
SMILES
Chemical Name
Formula	C18H17F2N3O2	M. Wt	345.34
Purity	98%	Storage	Store at 4-8°C
Description	BMS265246 inhibits the activity of CDK4/cycD with IC50 of 0.23 μM and prevents A2780 Cytox with IC50 of 0.76 μM. BMS265246 which binds to CDK2 shows the inhibitor resides coincident with the ATP purine binding site and forms important H-bonds with Leu83 on the protein backbone. BMS265246 exhibits CDK1 and CDK2 potency that is 25- and 11-fold more potent versus CDK1 and CDK2, respectively. BMS265246 represents the most potent CDK/CDK2 selective analogue from this chemotype. [1] A recent study shows that BMS-265246 inhibits cell proliferation with EC50 ranging from 0.293 μM-0.492 μM in HCT-116 cells. After treatment of BMS-265246, the dominant cell populations are G2-arrested cells having 4N DNA content, large round nuclei, and low DNA intensity.