ICA-069673
Data Sheet
For research use only. Not for human use.
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| CAS No. | 582323-16-8 | Cat. No. | BCP28988 |
| Name | ICA-069673 | ||
| Synonyms | ICA 069673; ICA069673; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C11H6ClF2N3O | M. Wt | 269.63 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ICA069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively). ICA-069673 inhibited spontaneous phasic, pharmacologically induced, and nerve-evoked contractions in DSM isolated strips in a concentration-dependent manner. . ICA-069673 decreased the global intracellular Ca(2+) concentration in DSM cells, an effect blocked by the L-type Ca(2+) channel inhibitor nifedipine. ICA-069673 hyperpolarized the membrane potential and inhibited spontaneous action potentials of isolated DSM cells, effects that were blocked in the presence of XE991. | ||
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