KU55933 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01834CAS No. ：587871-26-9Purity：98%

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CAS No.	587871-26-9	Cat. No.	BCP01834
Name	KU55933
Synonyms	KU-55933;KU 55933;ATM Kinase Inhibitor;
SMILES
Chemical Name
Formula	C21H17NO3S2	M. Wt	395.49
Purity	98%	Storage	Store at 4-8°C
Description	KU-55933 inhibits DNA-PK and PI3K with IC50 of 2.5 μM and 16.6 μM, respectively. Besides, KU-55933 also prevents the activity of mTOR with IC50 of 9.3 μM. KU-55933 is active at the cellular level in ablating a well-characterized ATM-dependent phosphorylation event. KU-55933 has a dose-dependent effect in inhibiting this ATM-dependent phosphorylation event with IC50 of 300 nM. KU-58050 does not prevent the ATM-dependent phosphorylation of p53 serine 15 until a dose of 30 μM. Addition of KU-55933 has no appreciable effects on UV-induced phosphorylation of H2AX on serine 139, NBS1 on serine 343, CHK1 on serine 345, and SMC1 on serine 966. In stark contrast to the UV responses, KU-55933 ablates the ionizing radiation-induced phosphorylation of these ATM substrates. KU-55933 sensitizes HeLa cells to a range of ionizing radiation doses.KU-55933 inhibits the phosphorylation of Akt induced by growth factors in cancer cells. KU-55933 suppresses the proliferation of cancer cells.